"We have discovered that the genetic and environmental contexts of a mutation have a much greater influence on its expression in a given individual than we previously thought," emphasized Dr Alfonso Buil, lead author of this study. "Understanding the architecture of genetic expression constitutes an essential step in understanding the genetic bases of complex diseases," he adds.
The environment is very much involved in how genes activate and deactive, making it not simply a random phenomenon.
"...what now seems obvious: the organism should never have been relegated to the role of mere carrier of its genes." -- Denis Noble (2013) Physiology is rocking the foundations of evolutionary biology.